FDA approves new targeted breast cancer drug

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.

The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.

Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.

"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."

Cobleigh helped conduct the key studies of the drug at the Chicago facility.

The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.

The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.

Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.

FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.

Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.

FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer

Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.

Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.

Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.

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Stock futures rise after HP earnings, German data

NEW YORK (Reuters) - Stock index futures rose on Friday, indicating the S&P 500 may halt a two-day losing skid, boosted by positive economic data from Europe and better-than-expected earnings from Hewlett-Packard.

The S&P 500 <.spx> has dropped 1.9 percent over the past two sessions, its worst two-day drop since early November, putting the index on pace for its first weekly decline of the year. The retreat was triggered by minutes from the Federal Reserve's January meeting released earlier in the week which suggested stimulus measures may end earlier than thought.

Still, the index is up more than 5 percent for the year and has held the 1,500 support level.

Hewlett-Packard Co climbed 4.7 percent to $17.90 in premarket trading after the No. 1 personal computer maker's quarterly revenue and forecasts beat Wall Street expectations as it continued to cut costs under CEO Meg Whitman's turnaround plan.

The German Ifo business climate indicator for February rose to 107.4, its best one-month rise in more than two years, boosting optimism after Thursday's disappointing PMI data stoked concerns over the euro zone economy.

S&P 500 futures rose 6.4 points and were above fair value, a formula that evaluates pricing by taking into account interest rates, dividends and time to expiration on the contract. Dow Jones industrial average futures gained 28 points, and Nasdaq 100 futures added 10.5 points.

Insurer American International Group Inc reported fourth-quarter results that beat analysts' expectations, although Chief Executive Robert Benmosche said some employee bonuses will be smaller this year because the company did not meet all of its performance targets. Shares advanced 3.8 percent to $38.68 in premarket trading.

Marvell Technology Group Ltd rose 4.5 percent to $9.90 in premarket trade after the chipmaker forecast results this quarter that were largely above analysts' expectations as it gained market share in the hard-disk drive and flash-storage businesses.

Fellow chipmaker Texas Instruments Inc raised its quarterly dividend by a third and said it would buy back an additional $5 billion in stock.

According to Thomson Reuters data through Thursday morning, of 427 companies in the S&P 500 that have reported results, 69.3 percent have exceeded analysts' expectations, compared with a 62 percent average since 1994 and 65 percent over the past four quarters.

Fourth-quarter earnings for S&P 500 companies are estimated to have risen 5.9 percent, according to the data, above a 1.9 percent forecast at the start of the earnings season.

European shares advanced after the better-than-expected German survey, with the pan-European FTSEurofirst 300 index <.fteu3> up 1.1 percent. <.eu/>

Asian shares recouped some of the previous session's steep falls as investors reassessed concerns that the Federal Reserve may end its ultra-soft monetary policy earlier than expected, but weak U.S. and European data capped Friday's recovery.

(Editing by Bernadette Baum)

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Josh Brolin & Diane Lane: Inside Their Up-and-Down Marriage

By Dahvi Shira

02/22/2013 at 07:30 AM EST

Diane Lane and Josh Brolin

Steve Granitz/Wireimage

Josh Brolin and Diane Lane's eight-year marriage is ending in divorce, but the road wasn't always rocky for the occasionally tumultuous pair.

"We're very similar in that celebrity is not a necessity," Brolin, 45, told PEOPLE in 2003, after meeting his soon-to-be-bride, 48, the previous year through stepmom Barbra Streisand. "Everything is easy."

The simplicity seemingly continued for Brolin and his beauty, who wed the following year in a ceremony at the actor's central California ranch.

Though there was a bit of a rocky start to their marriage, the pair got on track in 2005. As Lane told PEOPLE at the time, "I feel much better having a strong man with me who makes me feel embraced and secure. It's wonderful."

With her first marriage to actor Christopher Lambert behind her, Lane went on to say, "I wasn't going to go relationship shopping with my young daughter. I didn't want her to get attached to something that wasn't going to last."

In 2008, Lane praised Brolin, telling Redbook: "It's just invigorating to be around him. Josh completes me because I'm so attracted to his otherness."

On Thursday, reps confirmed the pair split, with a source telling PEOPLE, "They've been separated for several months. This was a hard decision for both of them to make. They were together for 11 years, the relationship just ran its course."

News of the breakup came almost two months after Brolin was held for public intoxication just before midnight on New Year's Eve 2013. Released without charge, the actor was spotted without his wedding ring the following day, donning sunglasses, in Venice, Calif., where he seemed unfazed by the trouble as he ate with a male friend at Sauce on Hampton.

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Flu shot doing poor job of protecting older people

ATLANTA (AP) — It turns out this year's flu shot is doing a startlingly dismal job of protecting older people, the most vulnerable age group.

The vaccine is proving only 9 percent effective in those 65 and older against the harsh strain of the flu that is predominant this season, the Centers for Disease Control and Prevention said Thursday.

Health officials are baffled as to why this is so. But the findings help explain why so many older people have been hospitalized with the flu this year.

Despite the findings, the CDC stood by its recommendation that everyone over 6 months get flu shots, the elderly included, because some protection is better than none, and because those who are vaccinated and still get sick may suffer less severe symptoms.

"Year in and year out, the vaccine is the best protection we have," said CDC flu expert Dr. Joseph Bresee.

Overall, across the age groups studied, the vaccine's effectiveness was found to be a moderate 56 percent, which means those who got a shot have a 56 percent lower chance of winding up at the doctor with the flu. That is somewhat worse than what has been seen in other years.

For those 65 and older, the vaccine was only 27 percent effective against the three strains it is designed to protect against, the worst level in about a decade. It did a particularly poor job against the tough strain that is causing more than three-quarters of the illnesses this year.

It is well known that flu vaccine tends to protect younger people better than older ones. Elderly people have weaker immune systems that don't respond as well to flu shots, and they are more vulnerable to the illness and its complications, including pneumonia.

But health officials said they don't know why this year's vaccine did so poorly in that age group.

One theory, as yet unproven, is that older people's immune systems were accustomed to strains from the last two years and had more trouble switching gears to handle this year's different, harsh strain.

The preliminary data for senior citizens is less than definitive. It is based on fewer than 300 people scattered among five states.

But it will no doubt surprise many people that the effectiveness is that low, said Michael Osterholm, a University of Minnesota infectious-disease expert who has tried to draw attention to the need for a more effective flu vaccine.

Among infectious diseases, flu is considered one of the nation's leading killers. On average, about 24,000 Americans die each flu season, according to the CDC.

This flu season started in early December, a month earlier than usual, and peaked by the end of year. Hospitalization rates for people 65 and older have been some of the highest in a decade, at 146 per 100,000 people.

Flu viruses tend to mutate more quickly than others, so a new vaccine is formulated each year to target the strains expected to be the major threats. CDC officials have said that in formulating this year's vaccine, scientists accurately anticipated the strains that are circulating this season.

Because of the guesswork involved, scientists tend to set a lower bar for flu vaccine. While childhood vaccines against diseases like measles are expected to be 90 or 95 percent effective, a flu vaccine that's 60 to 70 percent effective in the U.S. is considered pretty good. By that standard, this year's vaccine is OK.

For senior citizens, a flu vaccine is considered pretty good if it's in the 30 to 40 percent range, said Dr. Arnold Monto, a University of Michigan flu expert.

A high-dose version of the flu shot was recently made available for those 65 and older, but the new study was too small to show whether that has made a difference.

The CDC estimates are based on about 2,700 people who got sick in December and January. The researchers traced back to see who had gotten shots and who hadn't. An earlier, smaller study put the vaccine's overall effectiveness at 62 percent, but other factors that might have influenced that figure weren't taken into account.

The CDC's Bresee said there is a danger in providing preliminary results because it may result in people doubting — or skipping — flu shots. But the figures were released to warn older people who got shots that they may still get sick and shouldn't ignore any serious flu-like symptoms, he said.

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Online:

CDC report: http://www.cdc.gov/mmwr

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Stock futures lower following jobless claims data

TORONTO, Feb 20 (Reuters) - Canada's Rebecca Marino, a rising star in women's tennis, stepped away from the sport in search of a normal life on Wednesday, weary of battling depression and cyber-bullies. Ranked number 38 in the world two years ago, the 22-year-old admitted she had long suffered from depression and was no longer willing to make the sacrifices necessary to reach the top. "After thinking long and hard, I do not have the passion or enjoyment to drive myself to the level I would like to be at in professional tennis," Marino explained in a conference call. ...

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Car Bomb In Syrian Capital Kills At Least 31, Opposition Says

Sana/European Pressphoto Agency

An injured man was carried near the site of a car bomb explosion in Damascus on Thursday.

In renewed violence reaching the center of the Syrian capital, a car bomb exploded in Damascus on Thursday near the headquarters of President Bashar al-Assad’s ruling party, killing more than two dozen people, mainly civilians but also some security forces, according to opposition sources.

The violence coincided with renewed talks among Mr. Assad’s adversaries who met in Cairo on Thursday to discuss the terms on which the opposition Syrian National Coalition is prepared to talk about a negotiated settlement to the conflict.

Reuters quoted a draft communiqué under discussion by the group as saying it was prepared to negotiate, but Mr. Assad and his security force commanders were “not part of any political solution in Syria.”

The Syrian Observatory for Human Rights, an anti-Assad group based in Britain that has a network of contacts in Syria, reported that at least 31 people were killed by the bomb which exploded in the neighborhood of Mazraa.

Syrian state television said two children were wounded, while Al Ikhbariya, a pro-government television channel, showed footage of two dead bodies and body parts in a park.

The area where the bomb exploded was near the headquarters of Mr. Assad’s ruling Baath Party and the Russian Embassy. State television and the Syrian Observatory also said that mortar shells exploded near the Syrian Army General Command in the center of the capital, but there were no reported casualties.

The strikes were the latest to extend to the heart of the Syrian capital.

Reports this week appeared to show that rebel shells have reached new areas in Damascus.

State media and opposition activists reported on Wednesday that mortar rounds had hit the Tishreen sports stadium in the downtown neighborhood of Baramkeh. The state news agency, SANA, said the explosion killed an athlete from the Homs-based soccer team Al Wathba as he was practicing.

Government forces hit a rebel command center in a suburb east of the capital on Wednesday, injuring a founder of the Liwaa al-Islam brigade, Sheik Zahran Alloush, the brigade said in a statement.

On Tuesday, activists reported that up to seven mortar rounds had been fired by fighters of the Free Syrian Army toward Mr. Assad’s Tishreen Palace in Damascus.

There were no immediate reports of casualties, and it was not known whether Mr. Assad was there at the time. The palace, surrounded by a park, is in a wealthy area that has largely been insulated from the insurgency and it lies less than a mile from the main presidential palace.

Syrian rebels are entrenched in suburbs south and east of the capital, but they have been unable to push far into the center, although they strike the area with occasional mortars and increasingly frequent car bombs.

Such indiscriminate attacks, however, risk killing passers-by, exposing the rebels to charges that they are careless with civilian life and property. Many Damascus residents are undecided in the civil war and fear their ancient city will be ravaged like Aleppo and other urban centers to the north.

At the same time, the government has decimated pro-rebel suburbs with airstrikes and artillery, leaving vast areas depopulated or terrorized.

Fighting continued also for control of the main civilian airport in Aleppo on Wednesday.

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On Twitter, a peanut gallery mocks the Oscars

NEW YORK (AP) — You can simply tune into the Oscars. Or you can watch them with the peanut gallery on Twitter.

While Hollywood parades in tuxedos and gowns, grandly celebrating itself, a freewheeling cacophony of quips and sarcasm — something like a digital, million-times multiplied version of those balcony Muppet onlookers, Statler and Waldorf — will provide a welcome and riotous counter-narrative to the pomp.

The second-screen experience is never better than on Oscar night, when a separate (and some might say superior) entertainment experience plays out on social media. The running commentary, in which comedians and others parody the glamorous stars and their sometimes laughable speeches, has become as central to the Academy Awards as the red carpet.

“Following the Oscars on Twitter is like watching the show with one hundred million of your drunkest friends,” says Andy Borowitz, the humorist and author who’s often been a standout tweeter on Oscar night. Last year, he succinctly summarized the previous two best-picture winners, “The King’s Speech” and “The Artist,” as “an English dude who couldn’t speak” and “a French dude no one could hear.”

Live tweeting major TV events, from the Super Bowl to the Grammy Awards, has become engrained in our viewing by now, forming a virtual water cooler that has boosted ratings. But the Academy Awards stream is particularly captivating because it provides an antidote to the on-screen, buttoned-down glamour. It’s as if there’s not an “SAP” button on your remote, but a “YUKS” one, bringing you play-by-play from some of the funniest people in cyberspace. Comedians assemble as if by duty.

“You gotta say something. Someone has to say something,” says comedian Billy Eichner. “To just stand by and watch it happen is almost too tense. It’s cathartic. You’ve got to just get it out on Twitter because if not, we’re all going to be bottled up thinking about how awkward Anne Hathaway made it for one billion people in real time. I don’t begrudge her the award; I’m just saying she’s a ridiculous person.”

As host of Funny or Die’s “Billy on the Street,” which airs on Fuse, Eichner aggressively and comically interviews passersby about pop culture. So he’s particularly adept at expressing all-caps mockery when it comes to the stars of Hollywood. In the awards circuit leading up to the Oscars, he’s zeroed in on Anne Hathaway, the odds-on favorite to win best supporting actress for her performance in “Les Miserables.”

In Hathaway, Eichner recognizes a great actress, but also a striving theater geek. Nothing is funnier, he says, “than the mix of ego and lack of self-awareness, like Jodie Foster’s Golden Globes speech.”

“Ultimately, it’s just fun because the whole thing is so ridiculous,” says Eichner. “It’s like, why not comment on it? What is it even there for other than to be commented on?”

The Oscars has become one of the biggest social media events of the year. Last year’s telecast at one point set a then-record for 18,718 tweets-per-second. A statuette could be handed out for a new award: most tweeted tweet. In 2011, that honor went to The Onion, which lamented: “How rude — not a single character from Toy Story 3 bothered to show up.”

Last year, “The Artist” may have won best picture, but Martin Scorsese’s “Hugo” easily bested it with 110,179 tweets to 78,509 for “The Artist,” according to Twitter metrics analyst TweetReach.

This year, the academy has partnered with Twitter to track the top categories with an index measuring the percentage of positive tweets about the nominees. Leading as of Tuesday wasn’t the favorite “Argo,” nor was it Steven Spielberg’s “Lincoln,” but rather David O. Russell’s “Silver Linings Playbook.” So if the film, widely considered the dark horse in the best picture race, wins on Sunday, Twitter will have predicted it.

Mark Ghuneim, chief executive of social media measurement firm Trendrr, says that during the Oscars, Twitter is “‘Mystery Science Theater 3000,’ for real,” referring to the cult TV show in which a man and two robot sidekicks wisecrack their way through B-movies.

“It’s really like you’ll never watch TV alone ever again, if you don’t want to,” says Ghuneim. “It’s a natural evolution in television and that’s why it’s so prevalent.”

With real-time data from services like Trendrr, the Oscar conversation can be tracked, revealing which moments resound and provoke audiences. Last year, Angelina Jolie’s leg-baring pose as a presenter immediately put Twitter in hyper-drive, spawning parody accounts from the perspective of her right leg.

It’s such moments where Twitter becomes Oscar’s dance partner. Viewers celebrate with — and chortle at — Hollywood’s self-seriousness, combining together for a TV experience greater than the sum of its parts.

When the 85th annual Academy Awards air Sunday on ABC, countless comedians and others at home will be ready on their mobile phones and laptops with tweets to skewer.

“I just pray we all survive Anne Hathaway’s acceptance speech,” says Eichner. “And, to be honest, I have my doubts.”

___

Online:

https://oscars.twitter.com

___

Follow AP Entertainment Writer Jake Coyle on Twitter at: http://twitter.com/jake_coyle

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Lou Myers, A Different World Actor, Dies

By Tim Nudd

02/21/2013 at 08:25 AM EST

TV, film and stage actor Lou Myers, best known for playing Mr. Gaines on the sitcom A Different World in the '80s and early '90s, has died at 77.

Myers passed away at the Charleston Area Medical Center in his native state of West Virginia after battling pneumonia for several months, TMZ.com reported.

Myers was born in Chesapeake, W.V., the son of a Cabin Creek coal miner, according to the Charleston Gazette. After attending West Virginia State University, he got his first acting break as an understudy in the Broadway play The First Breeze of Summer.

He went on to appear in more than a dozen films, including How Stella Got Her Groove Back and The Wedding Planner.

On television, he had roles on ER, JAG and NYPD Blue, but is best remembered for playing Vernon Gaines on A Different World, which was a spin-off from The Cosby Show.

On Broadway, Myers appeared in productions including Oprah Winfrey's The Color Purple and Cat on a Hot Tin Roof. He won an NAACP Image Award for his portrayal of the Stool Pigeon in the play King Hedley II.

An accomplished piano player, Myers also sang jazz and blues with the touring company of Negro Music in Vogue.

He is survived by his mother, Dorothy Jeffries, 95, a son, Melvin Myers, and two grandsons, Brayden and Christian, the Gazette said.

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Adults get 11 percent of calories from fast food

ATLANTA (AP) — On an average day, U.S. adults get roughly 11 percent of their calories from fast food, a government study shows.

That's down slightly from the 13 percent reported the last time the government tried to pin down how much of the American diet is coming from fast food. Eating fast food too frequently has been seen as a driver of America's obesity problem.

For the research, about 11,000 adults were asked extensive questions about what they ate and drank over the previous 24 hours to come up with the results.

Among the findings:

— Young adults eat more fast food than their elders; 15 percent of calories for ages 20 to 39 and dropping to 6 percent for those 60 and older.

— Blacks get more of their calories from fast-food, 15 percent compared to 11 percent for whites and Hispanics.

— Young black adults got a whopping 21 percent from the likes of Wendy's, Taco Bell and KFC.

The figures are averages. Included in the calculations are some people who almost never eat fast food, as well as others who eat a lot of it.

The survey covers the years 2007 through 2010 and was released Thursday by the Centers for Disease Control and Prevention. The authors couldn't explain why the proportion of calories from fast food dropped from the 13 percent found in a survey for 2003 through 2006.

One nutrition professor cast doubts on the latest results, saying 11 percent seemed implausibly low. New York University's Marion Nestle said it wouldn't be surprising if some people under-reported their hamburgers, fries and milkshakes since eating too much fast food is increasingly seen as something of a no-no.

"If I were a fast-food company, I'd say 'See, we have nothing to do with obesity! Americans are getting 90 percent of their calories somewhere else!'" she said.

The study didn't include the total number of fast-food calories, just the percentage. Previous government research suggests that the average U.S. adult each day consumes about 270 calories of fast food — the equivalent of a small McDonald's hamburger and a few fries.

The new CDC study found that obese people get about 13 percent of daily calories from fast food, compared with less than 10 percent for skinny and normal-weight people.

There was no difference seen by household income, except for young adults. The poorest — those with an annual household income of less than $30,000 — got 17 percent of their calories from fast food, while the figure was under 14 percent for the most affluent 20- and 30-somethings with a household income of more than $50,000.

That's not surprising since there are disproportionately higher numbers of fast-food restaurants in low-income neighborhoods, Nestle said.

Fast food is accessible and "it's cheap," she said.

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Stock futures edge lower ahead of data, Fed minutes

NEW YORK (Reuters) - U.S. stock index futures edged lower on Wednesday, ahead of data on the housing market and inflation, as well as minutes from the Federal Open Market Committee's January meeting.

Housing starts and permits for January along with the January producer price index are due at 8:30 a.m. (1330 GMT).

Economists in a Reuters survey forecast the housing starts data to show a 925,000-unit annualized rate in January versus 954,000 in December, and a total of 915,000 permits in January compared with 909,000 in the prior month.

PPI is expected to show a 0.4 percent rise after a 0.3 percent drop in December. Excluding volatile food and energy items, PPI is expected to rise 0.2 percent versus a 0.1 percent increase in December.

Later in the session, investors will look to the minutes from the Fed's January meeting for any clues on how long the current monetary policy will remain in effect.

"We have several economic pieces of news today and of course the one that is eyed the most is going to be the FOMC minutes," said Peter Cardillo, chief market economist at Rockwell Global Capital in New York.

"Housing starts is in play and the earlier data probably will set the stage for the market to perhaps continue yesterday's rally but the key will be the FOMC minutes."

U.S. stocks moved closer to all-time highs on Tuesday, as the ongoing flurry of merger activity to start the year has helped buoy equities from a pullback.

An expected deal that helped lift the market on Tuesday was confirmed on Wednesday when Office Depot Inc said it had reached a definitive deal to buy smaller rival OfficeMax Inc in a bid to get more clout with suppliers and better compete against rival Staples Inc .

Office Depot shares jumped 14.5 percent to $5.75 before the opening bell while OfficeMax surged 15.4 percent to $15. Staples shares gained 2.7 percent to $15.05.

The S&P 500 <.spx> is up 7.4 percent for the year, fueled by legislators' ability to sidestep an automatic implementation of spending cuts on tax hikes on January 1, better-than-expected corporate earnings and modestly improving economic data that has been tepid enough for the Fed to maintain its stimulus policy.

S&P 500 futures slipped 1.4 points and were slightly below fair value, a formula that evaluates pricing by taking into account interest rates, dividends and time to expiration on the contract. Dow Jones industrial average futures lost 1 point, and Nasdaq 100 futures shed 3.75 points.

As earnings season winds down, S&P 500 companies set to report include Devon Energy Corp and Fluor Corp .

Toll Brothers Inc lost 4.6 percent to $35.20 in premarket trade after the largest luxury homebuilder in the United States, reported first-quarter results well below analysts' estimates.

SodaStream dropped 5 percent to $49.82 in premarket after the seller of home carbonated drink maker machines posted fourth-quarter earnings and provided a 2013 outlook.

According to Thomson Reuters data through Tuesday morning, of the 391 companies in the S&P 500 that have reported results, 70.1 percent have exceeded analysts' expectations, compared with a 62 percent average since 1994 and 65 percent over the past four quarters.

Fourth-quarter earnings for S&P 500 companies are estimated to have risen 5.6 percent, according to the data, above a 1.9 percent forecast at the start of the earnings season.

European shares dipped on Wednesday, consolidating after a steep rally in the previous session as investors were confronted with news of weak earnings, though some expected further near-term gains. <.eu/>

Asian shares scaled their highest levels since August 2011 after an improving global economic outlook whetted investor appetite for risk, while the yen firmed amid doubts over Japan's commitment to drastic reflation.

(Reporting by Chuck Mikolajczak; Editing by Chizu Nomiyama and Nick Zieminski)

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